Sizing up the ER stress response
نویسندگان
چکیده
منابع مشابه
Choosing the right response to ER stress
Cells use distinct unfolded protein response transducers to export different collagens during development.
متن کاملER stress and the unfolded protein response.
Conformational diseases are caused by mutations altering the folding pathway or final conformation of a protein. Many conformational diseases are caused by mutations in secretory proteins and reach from metabolic diseases, e.g. diabetes, to developmental and neurological diseases, e.g. Alzheimer's disease. Expression of mutant proteins disrupts protein folding in the endoplasmic reticulum (ER),...
متن کاملER stress PERKs up an miRNA
ER stress PERKs up an miRNA B yrd et al. describe how a microRNA (miRNA) fi ne-tunes a cell's response to ER stress. When stressful conditions disrupt the ER's normal function, the cell activates an unfolded protein response (UPR) that restores the organelle's ability to fold and export proteins to the secretory pathway. The transcription factor XBP1 is a key component of the UPR that boosts ER...
متن کاملLosing p53 loosens up ER-stress
endoplasmic reticulum (ER) is the central intracellular organelle responsible for proper folding, localization, and post-translational modifications of proteins in eukaryotic cells. During conditions of cellular stress, incorrectly folded proteins can accumulate in the ER and trigger the unfolded protein response (UPR), which involves the activation of signal transduction pathways designed to r...
متن کاملHeat shock response relieves ER stress.
Accumulation of misfolded protein in the endoplasmic reticulum (ER) causes stress. The unfolded protein response (UPR), a transcriptional induction pathway, is activated to relieve ER stress. Although UPR is not essential for viability, UPR-deficient cells are more sensitive to ER stress; ire1Delta cells cannot grow when challenged with tunicamycin or by overexpression of misfolded CPY(*). In t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2009
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1874iti3